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Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasia

Robson, Holly; Keidel, James L; Lambon Ralph, Matthew A; Sage, Karen; (2012) Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasia. Neuropsychologia , 50 (2) pp. 276-288. 10.1016/j.neuropsychologia.2011.11.022. Green open access

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Abstract

Wernicke's aphasia is a condition which results in severely disrupted language comprehension following a lesion to the left temporo-parietal region. A phonological analysis deficit has traditionally been held to be at the root of the comprehension impairment in Wernicke's aphasia, a view consistent with current functional neuroimaging which finds areas in the superior temporal cortex responsive to phonological stimuli. However behavioural evidence to support the link between a phonological analysis deficit and auditory comprehension has not been yet shown. This study extends seminal work by Blumstein, Baker, and Goodglass (1977) to investigate the relationship between acoustic–phonological perception, measured through phonological discrimination, and auditory comprehension in a case series of Wernicke's aphasia participants. A novel adaptive phonological discrimination task was used to obtain reliable thresholds of the phonological perceptual distance required between nonwords before they could be discriminated. Wernicke's aphasia participants showed significantly elevated thresholds compared to age and hearing matched control participants. Acoustic–phonological thresholds correlated strongly with auditory comprehension abilities in Wernicke's aphasia. In contrast, nonverbal semantic skills showed no relationship with auditory comprehension. The results are evaluated in the context of recent neurobiological models of language and suggest that impaired acoustic–phonological perception underlies the comprehension impairment in Wernicke's aphasia and favour models of language which propose a leftward asymmetry in phonological analysis.

Type: Article
Title: Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuropsychologia.2011.11.022
Publisher version: https://doi.org/10.1016/j.neuropsychologia.2011.11...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Wernicke's Aphasia, Comprehension, Phonology, Semantics, Auditory discrimination
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Language and Cognition
URI: https://discovery.ucl.ac.uk/id/eprint/10178734
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