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Determinants of health-related quality of life and global functioning and health in axSpA, pSpA, and PsA: results from the ASAS-PerSpA study

Santos, Helena; Henriques, Ana R; Machado, Pedro M; Lopez-Medina, Clementina; Dougados, Maxime; Canhão, Helena; Rodrigues, Ana M; (2023) Determinants of health-related quality of life and global functioning and health in axSpA, pSpA, and PsA: results from the ASAS-PerSpA study. Rheumatology , Article kead503. 10.1093/rheumatology/kead503. (In press).

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Abstract

Objectives: We aim to identify determinants of health-related quality of life (HRQoL) and global functioning and health (GH) in axial spondyloarthritis (axSpA), peripheral spondyloarthritis (pSpA), and psoriatic arthritis (PsA). // Methods: ASAS-perSpA study data were analyzed. Models for the three patient groups were performed separately to explore factors associated with HRQoL and GH, assessed by EQ-5D and ASAS-HI, respectively. // Results: The analyses included 4185 patients: 2719 with axSpA, 433 with pSpA, and 1033 with PsA. In axSpA, disease activity (DA) (β=-0.061), physical function (β=-0.041), female sex (β=-0.019), and fibromyalgia (β=-0.068) were associated with worse HRQoL; age (β = 0.001) and university education (β = 0.014) with better HRQoL. In pSpA, DA (β=-0.04) and physical function (β=-0.054) were associated with worse HRQoL. In PsA, DA (β=-0.045), physical function (β=-0.053), axial disease (β=-0.041), and female sex (β=-0.028) were associated with worse HRQoL. In axSpA, DA (β = 0.889), physical function (β = 0.887), peripheral disease (β = 0.564), female sex (β = 0.812) and fibromyalgia (β = 1.639) were associated with worse GH; age (β=-0.013) and university education (β=-0.274) with better GH. In pSpA, physical function (β = 1.142), and female sex (β = 1.060) were associated with worse GH; university education (β=-0.611) with better GH. In PsA, DA (β = 0.703), physical function (β = 1.025), axial involvement (β = 0.659), female sex (β = 0.924), and fibromyalgia (β = 1.387) were associated with worse GH; age (β=-0.024) and university education (β=-0.856) with better GH. // Conclusions: DA and physical function are major HRQoL and GH determinants across spondyloarthritis types, and clinical characteristics and sociodemographic factors play an important role, highlighting the importance of a holistic approach for individual patients.

Type: Article
Title: Determinants of health-related quality of life and global functioning and health in axSpA, pSpA, and PsA: results from the ASAS-PerSpA study
Location: England
DOI: 10.1093/rheumatology/kead503
Publisher version: https://doi.org/10.1093/rheumatology/kead503
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Determinants, quality-of-life, EQ-5D, global-health, ASAS-HI, spondyloarthritis, psoriatic arthritis, outcomes, PerSpA, burden
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10178238
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