UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation

Chawda, Mira M; Ross, Susan; Lau, Ching-In; Yánez, Diana C; Rowell, Jasmine; Kilbride, Peter; Crompton, Tessa; (2023) Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation. European Journal of Immunology , 53 (12) , Article 2350546. 10.1002/eji.202350546. Green open access

[thumbnail of Chawda_Eur J Immunol - 2023 - Chawda - Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on.pdf]
Preview
Text
Chawda_Eur J Immunol - 2023 - Chawda - Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on.pdf

Download (1MB) | Preview

Abstract

Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.

Type: Article
Title: Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/eji.202350546
Publisher version: https://doi.org/10.1002/eji.202350546
Language: English
Additional information: Copyright © 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Clinical immunology, Cryopreservation, Thymopoiesis, Thymus transplantation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10178192
Downloads since deposit
2Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item