Chawda, Mira M;
Ross, Susan;
Lau, Ching-In;
Yánez, Diana C;
Rowell, Jasmine;
Kilbride, Peter;
Crompton, Tessa;
(2023)
Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.
European Journal of Immunology
, 53
(12)
, Article 2350546. 10.1002/eji.202350546.
Preview |
Text
Chawda_Eur J Immunol - 2023 - Chawda - Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on.pdf Download (1MB) | Preview |
Abstract
Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.
| Type: | Article |
|---|---|
| Title: | Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/eji.202350546 |
| Publisher version: | https://doi.org/10.1002/eji.202350546 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Clinical immunology, Cryopreservation, Thymopoiesis, Thymus transplantation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10178192 |
Archive Staff Only
 |
View Item |
