Bueno, Clara;
Torres-Ruíz, Raul;
Velasco-Hernandez, Talia;
Molina, Oscar;
Petazzi, Paolo;
Martinez-Moreno, Alba;
Rodríguez-Cortez, Virginia Carolina;
... Menendez, Pablo; + view all
(2023)
A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features.
Blood
10.1182/blood.2023020858.
(In press).
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Abstract
The cellular ontogeny and location of the MLL-breakpoint influence the capacity of MLL-edited CD34+ HSPCs to initiate pro-B-ALL, and recapitulate the molecular features of MLL-AF4+ infant B-ALL patients. We provide key insights into the cellular-molecular leukemogenic determinants of MLL-AF4+ infant B-ALL.
| Type: | Article |
|---|---|
| Title: | A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1182/blood.2023020858 |
| Publisher version: | https://doi.org/10.1182/blood.2023020858 |
| Language: | English |
| Additional information: | Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved. (https://creativecommons.org/licenses/by/4.0/) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10178148 |
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