Wagstaff, Duncan;
Becker, Christian M;
(2008)
Do we know what causes endometriosis?
British Journal of Hospital Medicine
, 69
(6)
pp. 314-315.
10.12968/hmed.2008.69.6.29617.
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Abstract
Edometriosis is one of the most intensively investigated benign gynaecological disorders, but our understanding of its causation remains surprisingly incomplete. Several theories exist: coelomic metaplasia, induction, retrograde menstruation and implantation, Müllerian remnants and the archimetra concept. These hypotheses show various extents of plausibility and supporting scientific data. While the theory of retrograde menstruation and implantation is the most widely accepted, no single concept explains all forms and appearances of endometriosis. Indeed, the wide variety in incidence and progression of the disease seem to defy an explanation by a single mechanism which may indicate that endometriosis is a heterogenous disease. In addition, there is considerable overlap between most of the proposed theories
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