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Self-Reporting Theranostic: Nano Tool for Arterial Thrombosis

Deb, Suryyani; Azharuddin, Mohammad; Ramström, Sofia; Ghosh, Kanjaksha; Singha, Santiswarup; Romu, Thobias; Patra, Hirak Kumar; (2023) Self-Reporting Theranostic: Nano Tool for Arterial Thrombosis. Bioengineering , 10 (9) , Article 1020. 10.3390/bioengineering10091020. Green open access

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Abstract

Arterial thrombosis (AT) originates through platelet-mediated thrombus formation in the blood vessel and can lead to heart attack, stroke, and peripheral vascular diseases. Restricting the thrombus growth and its simultaneous monitoring by visualisation is an unmet clinical need for a better AT prognosis. As a proof-of-concept, we have engineered a nanoparticle-based theranostic (combined therapy and monitoring) platform that has the potential to monitor and restrain the growth of a thrombus concurrently. The theranostic nanotool is fabricated using biocompatible super-paramagnetic iron oxide nanoparticles (SPIONs) as a core module tethered with the anti-platelet agent Abciximab (ReoPro) on its surface. Our in vitro feasibility results indicate that ReoPro-conjugated SPIONS (Tx@ReoPro) can effectively prevent thrombus growth by inhibiting fibrinogen receptors (GPIIbIIIa) on the platelet surface, and simultaneously, it can also be visible through non-invasive magnetic resonance imaging (MRI) for potential reporting of the real-time thrombus status.

Type: Article
Title: Self-Reporting Theranostic: Nano Tool for Arterial Thrombosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/bioengineering10091020
Publisher version: https://doi.org/10.3390/bioengineering10091020
Language: English
Additional information: Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Keywords: arterial thrombosis; theranostics; platelet aggregations; MRI; ReoPro
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10177031
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