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Melatonin as a Therapy for Preterm Brain Injury: What Is the Evidence?

Häusler, S; Robertson, NJ; Golhen, K; van den Anker, J; Tucker, K; Felder, TK; (2023) Melatonin as a Therapy for Preterm Brain Injury: What Is the Evidence? Antioxidants , 12 (8) , Article 1630. 10.3390/antiox12081630. Green open access

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Abstract

Despite significant improvements in survival following preterm birth in recent years, the neurodevelopmental burden of prematurity, with its long-term cognitive and behavioral consequences, remains a significant challenge in neonatology. Neuroprotective treatment options to improve neurodevelopmental outcomes in preterm infants are therefore urgently needed. Alleviating inflammatory and oxidative stress (OS), melatonin might modify important triggers of preterm brain injury, a complex combination of destructive and developmental abnormalities termed encephalopathy of prematurity (EoP). Preliminary data also suggests that melatonin has a direct neurotrophic impact, emphasizing its therapeutic potential with a favorable safety profile in the preterm setting. The current review outlines the most important pathomechanisms underlying preterm brain injury and correlates them with melatonin’s neuroprotective potential, while underlining significant pharmacokinetic/pharmacodynamic uncertainties that need to be addressed in future studies.

Type: Article
Title: Melatonin as a Therapy for Preterm Brain Injury: What Is the Evidence?
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/antiox12081630
Publisher version: https://doi.org/10.3390/antiox12081630
Language: English
Additional information: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: Melatonin; preterm infants; inflammation; oxidative stress; oligodendrocyte dysmaturation; encephalopathy of prematurity; neuroprotection
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
URI: https://discovery.ucl.ac.uk/id/eprint/10176343
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