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Real world effectiveness of airway clearance techniques in children with cystic fibrosis

Filipow, Nicole; Stanojevic, Sanja; Raywood, Emma; Shannon, Harriet; Tanriver, Gizem; Kapoor, Kunal; Douglas, Helen; ... Main, Eleanor; + view all (2023) Real world effectiveness of airway clearance techniques in children with cystic fibrosis. European Respiratory Journal , 62 (3) , Article 2300522. 10.1183/13993003.00522-2023. Green open access

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Abstract

BACKGROUND: Cystic Fibrosis (CF) is commonly characterised by thick respiratory mucous. From diagnosis, people with CF are prescribed daily physiotherapy, including airway clearance treatments (ACTs). ACTs consume a large proportion of treatment time, yet the efficacy and effectiveness of ACTs are poorly understood. This study aimed to evaluate associations between quality and quantity of ACTs and lung function in children and young people with CF. METHODS: Project Fizzyo, a longitudinal observational cohort study, used remote-monitoring electronic pressure sensors with 4 different commercial ACT devices to record real-time, breath-by-breath pressure data during usual ACTs undertaken at home over 16 months in 145 children. ACTs were categorised either as conformant or not with current ACT recommendations based on breath pressure and length measurements, or as missed treatments if not recorded. Daily, weekly and monthly associations between ACT category and lung function were investigated using linear mixed effects regression models adjusting for clinical confounders. RESULTS: After exclusions, 45 224 ACTs (135 individuals) and 21 069 days without treatments (141 individuals) were analysed. Average age of participants was 10.2 years (sd=2.9). Conformant ACTs (21%) had significantly higher FEV1 (mean effect size 0.23, 95%CI [0.19, 0.27]) than non-conformant (79%) or missed treatments. There was no benefit from non-conformant or missed treatments, and no significant difference in FEV1 between them (mean effect size 0.02 (95%CI, [-0.01, 0.05]). CONCLUSION: ACTs are beneficial when done as recommended, but most people use techniques that do not improve lung function. Work is needed to monitor and improve ACT quality and to increase the proportion of people doing effective airway clearance at home.

Type: Article
Title: Real world effectiveness of airway clearance techniques in children with cystic fibrosis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1183/13993003.00522-2023
Publisher version: https://doi.org/10.1183/13993003.00522-2023
Language: English
Additional information: Copyright © The authors 2023. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10176282
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