Murayama, Hiroaki;
Pearson, Carl AB;
Abbott, Sam;
Miura, Fuminari;
Jung, Sung-mok;
Fearon, Elizabeth;
Funk, Sebastian;
(2023)
Accumulation of Immunity in Heavy-Tailed Sexual Contact Networks Shapes Mpox Outbreak Sizes.
The Journal of Infectious Diseases
, Article jiad254. 10.1093/infdis/jiad254.
(In press).
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Abstract
Many countries affected by the global outbreak of mpox in 2022 have observed a decline in cases. Our mathematical model accounting for heavy-tailed sexual partnership distributions suggests that mpox epidemics can hit the infection-derived herd immunity threshold and begin to decline with less than 1% of sexually active MSM population infected regardless of interventions or behavioural changes. Consistently, we found that many countries and US states experienced an epidemic peak with cumulative cases of around 0.1-0.5% of MSM population. The observed decline in cases may not necessarily be attributable to interventions or behavioural changes primarily.
Type: | Article |
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Title: | Accumulation of Immunity in Heavy-Tailed Sexual Contact Networks Shapes Mpox Outbreak Sizes |
Location: | United States |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1093/infdis/jiad254 |
Publisher version: | https://doi.org/10.1093/infdis/jiad254 |
Language: | English |
Additional information: | © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, Microbiology, depletion of susceptibles, heavy-tailed network, herd immunity, men who have sex with men, mpox |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health |
URI: | https://discovery.ucl.ac.uk/id/eprint/10176045 |
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