Ciurtin, Coziana;
Price, Elizabeth;
(2023)
A viewpoint on therapeutic approaches and unmet needs in the management of young people with juvenile Sjӧgren’s Syndrome.
touchREVIEWS in Respiratory & Pulmonary Diseases
(In press).
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Abstract
Sjögren disease (SjD) in children is a rare disease phenotype, categorized with onset before the age of 18. Due to differences in clinical presentation in children and young people compared with adults, the disease is under-recognised and under-diagnosed in younger patients. Consequently, no evidence-based treatment and management recommendations are available for children with SjD, despite efforts to develop paediatric expert-led consensus guidelines in recent years and incorporate management recommendations for children in adult guidelines. This article highlights the potential differences in assessment strategies for children and young people compared with adults due to differences in clinical manifestations and screening tests between SjD in children and adult-onset SjD. Furthermore, it summarises the evidence concerning the use and efficacy of various treatments in children with SjD. Higher-quality research is needed to evaluate the safety and efficacy of various off-label treatments used or recommended for use in child patients with SjD and investigate long-term disease outcomes.
| Type: | Article |
|---|---|
| Title: | A viewpoint on therapeutic approaches and unmet needs in the management of young people with juvenile Sjӧgren’s Syndrome |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://www.touchimmunology.com/paediatric-rheumat... |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Biologic therapies, children and adolescents, dryness, Sjögren disease in children, treatment, unmet needs |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10175962 |
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