Bruns, Christian;
Plaumann, Markus;
Herrmann, Tim;
Euchne, Frederike;
Kumar, Suchit;
Ringleb, Rainer;
Bernarding, Johannes;
(2019)
Temperature Sensitive 19F-Substituted Molecules for Combined Proton-/Fluorine-Imaging in a 7 T Whole-Body MRI System.
In:
Proceedings of the ISMRM 27th Annual Meeting & Exhibition.
ISMRM: Montréal, QC, Canada.
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Abstract
¹⁹F MR spectroscopy and imaging represent important tools for the development of new MR contrast agents and pharmaceutics. Until now, there are only a few published data that described the influence of temperature changes to the ¹⁹F chemical shifts in aqueous solutions. Temperature coefficients up to ~ 8.7Hz/K were determined. Thermoresponsive agents are of high interest in, e.g. hyperthermia studies. Changes in signal intensity and chemical shift give information of the local temperature. Here, we present novel MR spectroscopic and imaging data, which describe the ¹⁹F MR signal temperature dependency of different fluorinated organic substrates in isotonic saline solution and their temperature calculation methods.
| Type: | Proceedings paper |
|---|---|
| Title: | Temperature Sensitive 19F-Substituted Molecules for Combined Proton-/Fluorine-Imaging in a 7 T Whole-Body MRI System |
| Event: | 2021 ISMRM & SMRT Annual Meeting & Exhibition |
| Location: | Montréal, QC, Canada |
| Dates: | 11 May 2019 - 16 May 2019 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://cds.ismrm.org/protected/19MProceedings/PDF... |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10175065 |
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