Bui, LT;
Winters, NI;
Chung, MI;
Joseph, C;
Gutierrez, AJ;
Habermann, AC;
Adams, TS;
... Zaragosi, LE; + view all
(2021)
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Nature Communications
, 12
, Article 4314. 10.1038/s41467-021-24467-0.
Preview |
Text
s41467-021-24467-0.pdf - Published Version Download (4MB) | Preview |
Abstract
Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in patients with chronic lung diseases. We observe a similar cellular distribution and relative expression of SARS-CoV-2 entry factors in control and CLD lungs. CLD AT2 cells express higher levels of genes linked directly to the efficiency of viral replication and the innate immune response. Additionally, we identify basal differences in inflammatory gene expression programs that highlight how CLD alters the inflammatory microenvironment encountered upon viral exposure to the peripheral lung. Our study indicates that CLD is accompanied by changes in cell-type-specific gene expression programs that prime the lung epithelium for and influence the innate and adaptive immune responses to SARS-CoV-2 infection.
| Type: | Article |
|---|---|
| Title: | Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-021-24467-0 |
| Publisher version: | https://doi.org/10.1038/s41467-021-24467-0 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Alveolar Epithelial Cells, Angiotensin-Converting Enzyme 2, COVID-19, Chronic Disease, Humans, Idiopathic Pulmonary Fibrosis, Immunity, Innate, Inflammation, Lung, Lung Diseases, SARS-CoV-2, Transcriptome, Virus Internalization, Virus Replication |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10174992 |
Archive Staff Only
 |
View Item |
