UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Effective resting-state connectivity in severe unipolar depression before and after electroconvulsive therapy

Ten Doesschate, Freek; Bruin, Willem; Zeidman, Peter; Abbott, Christopher C; Argyelan, Miklos; Dols, Annemieke; Emsell, Louise; ... van Wingen, Guido A; + view all (2023) Effective resting-state connectivity in severe unipolar depression before and after electroconvulsive therapy. Brain Stimulation , 16 (4) pp. 1128-1134. 10.1016/j.brs.2023.07.054. Green open access

[thumbnail of 1-s2.0-S1935861X23018697-main.pdf]
Preview
PDF
1-s2.0-S1935861X23018697-main.pdf - Published Version

Download (2MB) | Preview

Abstract

BACKGROUND: Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depressive disorders. A recent multi-center study found no consistent changes in correlation-based (undirected) resting-state connectivity after ECT. Effective (directed) connectivity may provide more insight into the working mechanism of ECT. OBJECTIVE: We investigated whether there are consistent changes in effective resting-state connectivity. METHODS: This multi-center study included data from 189 patients suffering from severe unipolar depression and 59 healthy control participants. Longitudinal data were available for 81 patients and 24 healthy controls. We used dynamic causal modeling for resting-state functional magnetic resonance imaging to determine effective connectivity in the default mode, salience and central executive networks before and after a course of ECT. Bayesian general linear models were used to examine differences in baseline and longitudinal effective connectivity effects associated with ECT and its effectiveness. RESULTS: Compared to controls, depressed patients showed many differences in effective connectivity at baseline, which varied according to the presence of psychotic features and later treatment outcome. Additionally, effective connectivity changed after ECT, which was related to ECT effectiveness. Notably, treatment effectiveness was associated with decreasing and increasing effective connectivity from the posterior default mode network to the left and right insula, respectively. No effects were found using correlation-based (undirected) connectivity. CONCLUSIONS: A beneficial response to ECT may depend on how brain regions influence each other in networks important for emotion and cognition. These findings further elucidate the working mechanisms of ECT and may provide directions for future non-invasive brain stimulation research.

Type: Article
Title: Effective resting-state connectivity in severe unipolar depression before and after electroconvulsive therapy
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.brs.2023.07.054
Publisher version: https://doi.org/10.1016/j.brs.2023.07.054
Language: English
Additional information: © 2023 The Authors. Published by Elsevier Inc. under a Creative Commons license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10174945
Downloads since deposit
7Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item