Li, Kan Yan Chloe;
Dejea, Hector;
De Winne, Koen;
Bonnin, Anne;
D'Onofrio, Valentino;
Cox, Janneke A;
Garcia-Canadilla, Patricia;
... Dendooven, Amélie; + view all
(2023)
Feasibility and safety of synchrotron-based X-ray phase contrast imaging as a technique complementary to histopathology analysis.
Histochemistry and Cell Biology
10.1007/s00418-023-02220-6.
(In press).
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Abstract
X-ray phase contrast imaging (X-PCI) is a powerful technique for high-resolution, three-dimensional imaging of soft tissue samples in a non-destructive manner. In this technical report, we assess the quality of standard histopathological techniques performed on formalin-fixed, paraffin-embedded (FFPE) human tissue samples that have been irradiated with different doses of X-rays in the context of an X-PCI experiment. The data from this study demonstrate that routine histochemical and immunohistochemical staining quality as well as DNA and RNA analyses are not affected by previous X-PCI on human FFPE samples. From these data we conclude it is feasible and acceptable to perform X-PCI on FFPE human biopsies.
| Type: | Article |
|---|---|
| Title: | Feasibility and safety of synchrotron-based X-ray phase contrast imaging as a technique complementary to histopathology analysis |
| Location: | Germany |
| DOI: | 10.1007/s00418-023-02220-6 |
| Publisher version: | https://doi.org/10.1007/s00418-023-02220-6 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Needle biopsies, Pathology, X-ray phase contrast imaging |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Childrens Cardiovascular Disease |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10174615 |
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