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Casein fibres for wound healing

Ahmed, Jubair; Guler, Ece; Sinemcan Ozcan, Gul; Emin Cam, Muhammet; Homer-Vanniasinkam, Shervanthi; Edirisinghe, Mohan; (2023) Casein fibres for wound healing. Journal of the Royal Society. Interface , 20 (204) , Article 20230166. 10.1098/rsif.2023.0166. Green open access

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Abstract

The name casein is given to a family of phosphoproteins which is commonly found in milk. Until recently, this was a constituent of milk that was commonly discarded; however today, it is widely used in health supplements all over the world. In this work, a high loading (50 wt%) of casein is mixed with a solution of polycaprolactone (PCL) to produce bandage-like fibres with an average fibre diameter of 1.4 ± 0.5 µm, which would be used to cover wounds in a series of tests with diabetic rats. Mouse fibroblast cell viability tests show that the casein-loaded fibres had little cytotoxicity with over 90% observed viability. A 14-day in vivo trial involving three groups of rats, used as control (no treatment), pure PCL fibres and casein-loaded fibres, showed that the casein within the fibres contributed to a significantly more extensive healing process. Histological analysis showed increased development of granulation tissue and follicle regrowth for the casein-loaded fibres. Further analysis showed that casein-loaded fibres have significantly lower levels of TNF-α, TGF-β IL-1β, NF-κB and IL-6, contributing to superior healing. The results presented here show an economical and simple approach to advanced wound healing.

Type: Article
Title: Casein fibres for wound healing
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rsif.2023.0166
Publisher version: https://doi.org/10.1098/rsif.2023.0166
Language: English
Additional information: © 2023 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Keywords: wound healing, in vivo, fibres, casein, bandages
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10174308
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