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Diagnosis and management of Guillain–Barré syndrome in ten steps

Leonhard, SE; Mandarakas, MR; Gondim, FDAA; Bateman, K; Ferreira, MLB; Cornblath, DR; Van doorn, PA; ... Jacobs, BC; + view all (2021) Diagnosis and management of Guillain–Barré syndrome in ten steps. Nature Reviews Neurology , 81 (5) pp. 817-836. 10.1038/s41582-019-0250-9. Green open access

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Abstract

Guillain–Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and 2015 in Latin America. Diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous, and no international clinical guidelines are currently available. To support clinicians, especially in the context of an outbreak, we have developed a globally applicable guideline for the diagnosis and management of GBS. The guideline is based on current literature and expert consensus, and has a ten-step structure to facilitate its use in clinical practice. We first provide an introduction to the diagnostic criteria, clinical variants and differential diagnoses of GBS. The ten steps then cover early recognition and diagnosis of GBS, admission to the intensive care unit, treatment indication and selection, monitoring and treatment of disease progression, prediction of clinical course and outcome, and management of complications and sequelae.

Type: Article
Title: Diagnosis and management of Guillain–Barré syndrome in ten steps
Location: Argentina
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41582-019-0250-9
Publisher version: https://doi.org/10.1038/s41582-019-0250-9
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Guillain-Barré syndrome, Zika virus, ascending paralysis, diagnosis, guideline, management, Disease Outbreaks, Guillain-Barre Syndrome, Humans, Incidence, Zika Virus, Zika Virus Infection
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10174268
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