UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Use of albumin infusion for cirrhosis-related complications: An international position statement

Bai, Zhaohui; Méndez-Sánchez, Nahum; Romeiro, Fernando Gomes; Mancuso, Andrea; Philips, Cyriac Abby; Tacke, Frank; Basaranoglu, Metin; ... Liver Cirrhosis-related Complications (LCC)-International Specia; + view all (2023) Use of albumin infusion for cirrhosis-related complications: An international position statement. JHEP Reports , 5 (8) , Article 100785. 10.1016/j.jhepr.2023.100785. Green open access

[thumbnail of 1-s2.0-S2589555923001167-main.pdf]
Preview
PDF
1-s2.0-S2589555923001167-main.pdf - Published Version

Download (1MB) | Preview

Abstract

BACKGROUND & AIMS: Numerous studies have evaluated the role of human albumin (HA) in managing various liver cirrhosis-related complications. However, their conclusions remain partially controversial, probably because HA was evaluated in different settings, including indications, patient characteristics, and dosage and duration of therapy. METHODS: Thirty-three investigators from 19 countries with expertise in the management of liver cirrhosis-related complications were invited to organise an International Special Interest Group. A three-round Delphi consensus process was conducted to complete the international position statement on the use of HA for treatment of liver cirrhosis-related complications. RESULTS: Twelve clinically significant position statements were proposed. Short-term infusion of HA should be recommended for the management of hepatorenal syndrome, large volume paracentesis, and spontaneous bacterial peritonitis in liver cirrhosis. Its effects on the prevention or treatment of other liver cirrhosis-related complications should be further elucidated. Long-term HA administration can be considered in specific settings. Pulmonary oedema should be closely monitored as a potential adverse effect in cirrhotic patients receiving HA infusion. CONCLUSIONS: Based on the currently available evidence, the international position statement suggests the potential benefits of HA for the management of multiple liver cirrhosis-related complications and summarises its safety profile. However, its optimal timing and infusion strategy remain to be further elucidated. IMPACT AND IMPLICATIONS: Thirty-three investigators from 19 countries proposed 12 position statements on the use of human albumin (HA) infusion in liver cirrhosis-related complications. Based on current evidence, short-term HA infusion should be recommended for the management of HRS, LVP, and SBP; whereas, long-term HA administration can be considered in the setting where budget and logistical issues can be resolved. However, pulmonary oedema should be closely monitored in cirrhotic patients who receive HA infusion.

Type: Article
Title: Use of albumin infusion for cirrhosis-related complications: An international position statement
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jhepr.2023.100785
Publisher version: https://doi.org/10.1016/j.jhepr.2023.100785
Language: English
Additional information: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Decompensated, Human albumin, Kidney injury, Liver failure, Management, Portal hypertension, Sepsis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10174236
Downloads since deposit
21Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item