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Metabolic adaption of mucosal macrophages: Is metabolism a driver of persistence across tissues?

Bennett, Clare L; Perona-Wright, Georgia; (2023) Metabolic adaption of mucosal macrophages: Is metabolism a driver of persistence across tissues? Mucosal Immunology 10.1016/j.mucimm.2023.06.006. (In press). Green open access

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Abstract

Macrophages play essential roles in tissue homeostasis, defense, and repair. Their functions are highly tissue-specific, and when damage and inflammation stimulate repopulation by circulating monocytes, the incoming monocytes rapidly acquire the same, tissue-specific functions as the previous, resident macrophages. Several environmental factors are thought to guide the functional differentiation of recruited monocytes, including metabolic pressures imposed by the fuel sources available in each tissue. Here we discuss whether such a model of metabolic determinism can be applied to macrophage differentiation across barrier sites, from the lung to the skin. We suggest an alternative model, in which metabolic phenotype is a consequence of macrophage longevity rather than an early driver of tissue-specific adaption.

Type: Article
Title: Metabolic adaption of mucosal macrophages: Is metabolism a driver of persistence across tissues?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mucimm.2023.06.006
Publisher version: https://doi.org/10.1016/j.mucimm.2023.06.006
Language: English
Additional information: © 2023 The Author(s). Published by Elsevier Inc. on behalf of Society for Mucosal Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10173829
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