Chew, EY;
Peto, T;
Clemons, TE;
Sallo, FB;
Pauleikhoff, D;
Leung, I;
Jaffe, GJ;
... Friedlander, M; + view all
(2023)
Macular Telangiectasia Type 2: A Classification System Using MultiModal Imaging MacTel Project Report Number 10.
Ophthalmology Science
, 3
(2)
, Article 100261. 10.1016/j.xops.2022.100261.
Preview |
Text
Macular Telangiectasia Type 2 A Classification System Using MultiModal Imaging MacTel Project Report Number 10.pdf - Other Download (4MB) | Preview |
Abstract
Purpose: To develop a severity classification for macular telangiectasia type 2 (MacTel) disease using multimodal imaging. Design: An algorithm was used on data from a prospective natural history study of MacTel for classification development. Subjects: A total of 1733 participants enrolled in an international natural history study of MacTel. Methods: The Classification and Regression Trees (CART), a predictive nonparametric algorithm used in machine learning, analyzed the features of the multimodal imaging important for the development of a classification, including reading center gradings of the following digital images: stereoscopic color and red-free fundus photographs, fluorescein angiographic images, fundus autofluorescence images, and spectral-domain (SD)-OCT images. Regression models that used least square method created a decision tree using features of the ocular images into different categories of disease severity. Main Outcome Measures: The primary target of interest for the algorithm development by CART was the change in best-corrected visual acuity (BCVA) at baseline for the right and left eyes. These analyses using the algorithm were repeated for the BCVA obtained at the last study visit of the natural history study for the right and left eyes. Results: The CART analyses demonstrated 3 important features from the multimodal imaging for the classification: OCT hyper-reflectivity, pigment, and ellipsoid zone loss. By combining these 3 features (as absent, present, noncentral involvement, and central involvement of the macula), a 7-step scale was created, ranging from excellent to poor visual acuity. At grade 0, 3 features are not present. At the most severe grade, pigment and exudative neovascularization are present. To further validate the classification, using the Generalized Estimating Equation regression models, analyses for the annual relative risk of progression over a period of 5 years for vision loss and for progression along the scale were performed. Conclusions: This analysis using the data from current imaging modalities in participants followed in the MacTel natural history study informed a classification for MacTel disease severity featuring variables from SD-OCT. This classification is designed to provide better communications to other clinicians, researchers, and patients. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.
Type: | Article |
---|---|
Title: | Macular Telangiectasia Type 2: A Classification System Using MultiModal Imaging MacTel Project Report Number 10 |
Location: | Netherlands |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.xops.2022.100261 |
Publisher version: | https://doi.org/10.1016/j.xops.2022.100261 |
Language: | English |
Additional information: | Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | BCVA, best-corrected visual acuity, BLR, blue light reflectance, CART, Classification and Regression Trees, CF, color fundus, Classification, Classification and Regression Trees (CART), EZ, ellipsoid zone, FAF, fundus autoflorescence, FLIO, fluorescence lifetime imaging ophthalmoscopy, MacTel, macular telangiectasia type 2, Machine learning, Macular telangiectasia type 2, NHOR, natural history observation registry, NHOS, natural history observation study, Neurovascular degeneration, OCTA, OCT angiography, SD-OCT, spectral domain-OCT, VA, visual acuity |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
URI: | https://discovery.ucl.ac.uk/id/eprint/10173555 |
Archive Staff Only
View Item |