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Updates on radiotherapy-immunotherapy combinations: Proceedings of 6(th) annual ImmunoRad conference

Gregucci, Fabiana; Spada, Sheila; Barcellos-Hoff, Mary Helen; Bhardwaj, Nina; Hak, Charleen Chan Wah; Fiorentino, Alba; Guha, Chandan; ... Formenti, Silvia C; + view all (2023) Updates on radiotherapy-immunotherapy combinations: Proceedings of 6(th) annual ImmunoRad conference. OncoImmunology , 12 (1) , Article 2222560. 10.1080/2162402X.2023.2222560. Green open access

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Abstract

Focal radiation therapy (RT) has attracted considerable attention as a combinatorial partner for immunotherapy (IT), largely reflecting a well-defined, predictable safety profile and at least some potential for immunostimulation. However, only a few RT-IT combinations have been tested successfully in patients with cancer, highlighting the urgent need for an improved understanding of the interaction between RT and IT in both preclinical and clinical scenarios. Every year since 2016, ImmunoRad gathers experts working at the interface between RT and IT to provide a forum for education and discussion, with the ultimate goal of fostering progress in the field at both preclinical and clinical levels. Here, we summarize the key concepts and findings presented at the Sixth Annual ImmunoRad conference.

Type: Article
Title: Updates on radiotherapy-immunotherapy combinations: Proceedings of 6(th) annual ImmunoRad conference
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/2162402X.2023.2222560
Publisher version: https://doi.org/10.1080/2162402X.2023.2222560
Language: English
Additional information: © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
Keywords: dose and fractionation; FLASH radiotherapy; immune checkpoint inhibitors; immunomodulators; lymph node sparing; tumor-associated macrophages
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10172964
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