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What more can be done? Prioritizing the most promising antenatal interventions to improve birth weight

Koivu, Annariina M; Haapaniemi, Tiia; Askari, Sufia; Bhandari, Nita; Black, Robert E; Chico, R Matthew; Dewey, Kathryn G; ... LBW prevention prioritization working group; + view all (2023) What more can be done? Prioritizing the most promising antenatal interventions to improve birth weight. The American Journal of Clinical Nutrition , 117 (Supp 3) S107-S117. 10.1016/j.ajcnut.2022.10.022.

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Abstract

BACKGROUND: Low birth weight (LBW) is associated with neonatal mortality and sequelae of lifelong health problems; prioritizing the most promising antenatal interventions may guide resource allocation and improve health outcomes. OBJECTIVE: We sought to identify the most promising interventions that are not yet included in the policy recommendations of the World Health Organization (WHO) but could complement antenatal care and reduce the prevalence of LBW and related adverse birth outcomes in low- and middle-income settings. METHODS: We utilized an adapted Child Health and Nutrition Research Initiative (CHNRI) prioritization method. RESULTS: In addition to procedures already recommended by WHO for the prevention of LBW, we identified six promising antenatal interventions that are not currently recommended by WHO with an indication for LBW prevention, namely: (1) provision of multiple micronutrients; (2) low-dose aspirin; (3) high-dose calcium; (4) prophylactic cervical cerclage; (5) psychosocial support for smoking cessation; and (6) other psychosocial support for targeted populations and settings. We also identified seven interventions for further implementation research and six interventions for efficacy research. CONCLUSION: These promising interventions, coupled with increasing coverage of currently recommended antenatal care, could accelerate progress toward the global target of a 30% reduction in the number of LBW infants born in 2025 compared to 2006-10.

Type: Article
Title: What more can be done? Prioritizing the most promising antenatal interventions to improve birth weight
Location: United States
DOI: 10.1016/j.ajcnut.2022.10.022
Publisher version: https://doi.org/10.1016/j.ajcnut.2022.10.022
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Antenatal care (ANC), Child Health and Nutrition Research Initiative (CHNRI) method, Low birth weight (LBW), Low- and middle-income countries (LMICs), Preterm birth (PTB), Priority-setting, Infant, Newborn, Infant, Child, Pregnancy, Female, Humans, Birth Weight, Infant, Low Birth Weight, Prenatal Care, Pregnancy Complications, Nutritional Status
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10172408
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