Geng, Hongya;
Lupton, Emily J;
Ma, Yun;
Sun, Rujie;
Grigsby, Christopher L;
Brachi, Giulia;
Li, Xiaorui;
... Stevens, Molly M; + view all
(2023)
Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy.
Advanced Healthcare Materials
, Article e2301148. 10.1002/adhm.202301148.
(In press).
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Abstract
The development of near-infrared light (NIR)-responsive conductive polymers provides a useful theranostic platform for malignant tumours by maximizing spatial resolution with deep tissue penetration for diagnosis and photothermal therapy. Herein, we demonstrated the self-assembly of ultrathin two-dimensional (2D) polypyrrole nanosheets utilizing dopamine as a capping agent and a monolayer of octadecylamine as a template. The 2D polypyrrole-polydopamine nanostructure (DPPy) had tunable size distribution which showed strong absorption in the first and second near-infrared windows, enabling photoacoustic imaging and photothermal therapy. The hybrid double-layer was demonstrated to increase Raman intensity for 3D Raman imaging (up to two orders of magnitude enhancement and spatial resolution up to 1 μm). The acidic environment drove reversible doping of polypyrrole, which could be detected by Raman spectroscopy. The combined properties of the nanosheets could substantially enhance performance in dual-mode Raman and photoacoustic guided photothermal therapy, as shown by the 69% light to heat conversion efficiency and higher cytotoxicity against cancer spheroids. These pH-responsive features highlight the potential of 2D conductive polymers for applications in accurate, highly efficient theranostics. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/adhm.202301148 |
| Publisher version: | https://doi.org/10.1002/adhm.202301148 |
| Language: | English |
| Additional information: | © 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Conductive nanosheets, Photoacoustic imaging, Photothermal therapy, Polypyrrole, Raman imaging |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10172274 |
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