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Impact of puberty, sex determinants and chronic inflammation on cardiovascular risk in young people

Allalou, Amal; Peng, Junjie; Robinson, George A; Marruganti, Crystal; D’Aiuto, Francesco; Butler, Gary; Jury, Elizabeth C; (2023) Impact of puberty, sex determinants and chronic inflammation on cardiovascular risk in young people. Frontiers in Cardiovascular Medicine , 10 , Article 1191119. 10.3389/fcvm.2023.1191119. Green open access

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Abstract

Worrying trends of increased cardiovascular disease (CVD) risk in children, adolescents and young people in the recent decades have channelled research and public health strategies to tackle this growing epidemic. However, there are still controversies related to the dynamic of the impact of sex, age and puberty on this risk and on cardiovascular health outcomes later in life. In this comprehensive review of current literature, we examine the relationship between puberty, sex determinants and various traditional CVD-risk factors, as well as subclinical atherosclerosis in young people in general population. In addition, we evaluate the role of chronic inflammation, sex hormone therapy and health-risk behaviours on augmenting traditional CVD-risk factors and health outcomes, ultimately aiming to determine whether tailored management strategies for this age group are justified.

Type: Article
Title: Impact of puberty, sex determinants and chronic inflammation on cardiovascular risk in young people
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fcvm.2023.1191119
Publisher version: https://doi.org/10.3389/fcvm.2023.1191119
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Cardiovascular risk factors, children and young people, chronic inflammation, puberty, obesity, sex determinants
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10172183
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