ter Kuile, Abigail R;
Hübel, Christopher;
Cheesman, Rosa;
Coleman, Jonathan RI;
Peel, Alicia J;
Levey, Daniel F;
Stein, Murray B;
... Breen, Gerome; + view all
(2023)
Genetic Decomposition of the Heritable Component of Reported Childhood Maltreatment.
Biological Psychiatry Global Open Science
10.1016/j.bpsgos.2023.03.003.
(In press).
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Abstract
BACKGROUND: Decades of research have shown that environmental exposures, including self-reports of trauma, are partly heritable. Heritable characteristics may influence exposure to and interpretations of environmental factors. Identifying heritable factors associated with self-reported trauma could improve our understanding of vulnerability to exposure and the interpretation of life events. METHODS: We used genome-wide association study summary statistics of childhood maltreatment, defined as reporting of abuse (emotional, sexual, and physical) and neglect (emotional and physical) (N = 185,414 participants). We calculated genetic correlations (rg) between reported childhood maltreatment and 576 traits to identify phenotypes that might explain the heritability of reported childhood maltreatment, retaining those with |rg| > 0.25. We specified multiple regression models using genomic structural equation modeling to detect residual genetic variance in childhood maltreatment after accounting for genetically correlated traits. RESULTS: In 2 separate models, the shared genetic component of 12 health and behavioral traits and 7 psychiatric disorders accounted for 59% and 56% of heritability due to common genetic variants (single nucleotide polymorphism–based heritability [h2SNP]) of childhood maltreatment, respectively. Genetic influences on h2SNP of childhood maltreatment were generally accounted for by a shared genetic component across traits. The exceptions to this were general risk tolerance, subjective well-being, posttraumatic stress disorder, and autism spectrum disorder, identified as independent contributors to h2SNP of childhood maltreatment. These 4 traits alone were sufficient to explain 58% of h2SNP of childhood maltreatment. CONCLUSIONS: We identified putative traits that reflect h2SNP of childhood maltreatment. Elucidating the mechanisms underlying these associations may improve trauma prevention and posttraumatic intervention strategies.
| Type: | Article |
|---|---|
| Title: | Genetic Decomposition of the Heritable Component of Reported Childhood Maltreatment |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bpsgos.2023.03.003 |
| Publisher version: | https://doi.org/10.1016/j.bpsgos.2023.03.003 |
| Language: | English |
| Additional information: | © 2023 THE AUTHORS. Published by Elsevier Inc on behalf of the Society of Biological Psychiatry. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | Childhood adversity, Childhood trauma, Explained variance, Genetic correlations, GWAS, Maltreatment |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10172082 |
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