Garjani, Afagh;
Liu, Brandon Jun-Yu;
Allen, Christopher Martin;
Gunzler, Douglas David;
Gerry, Stephen William;
Planchon, Sarah Marie;
das Nair, Roshan;
... Evangelou, Nikos; + view all
(2022)
Decentralised clinical trials in multiple sclerosis research.
Multiple Sclerosis Journal
, 29
(3)
pp. 314-486.
10.1177/13524585221100401.
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Abstract
Randomised controlled trials (RCTs) play an important role in multiple sclerosis (MS) research, ensuring that new interventions are safe and efficacious before their introduction into clinical practice. Trials have been evolving to improve the robustness of their designs and the efficiency of their conduct. Advances in digital and mobile technologies in recent years have facilitated this process and the first RCTs with decentralised elements became possible. Decentralised clinical trials (DCTs) are conducted remotely, enabling participation of a more heterogeneous population who can participate in research activities from different locations and at their convenience. DCTs also rely on digital and mobile technologies which allows for more flexible and frequent assessments. While hospitals quickly adapted to e-health and telehealth assessments during the COVID-19 pandemic, the conduct of conventional RCTs was profoundly disrupted. In this paper, we review the existing evidence and gaps in knowledge in the design and conduct of DCTs in MS.
| Type: | Article |
|---|---|
| Title: | Decentralised clinical trials in multiple sclerosis research |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/13524585221100401 |
| Publisher version: | https://doi.org/10.1177/13524585221100401 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page |
| Keywords: | Clinical Neurology, clinical trial, COST-EFFECTIVENESS, Decentralised, digital, DISABILITY, FAIL, FRAMEWORK, Life Sciences & Biomedicine, multiple sclerosis, Neurosciences, Neurosciences & Neurology, randomised controlled trial, RECRUITMENT, remote, Science & Technology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10171996 |
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