UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Quality indicators for appropriate antibiotic prescribing in urinary tract infections in children

Vazouras, Konstantinos; Jackson, Charlotte; Folgori, Laura; Anastasiou-Katsiardani, Anastasia; Hsia, Yingfen; Basmaci, Romain; (2023) Quality indicators for appropriate antibiotic prescribing in urinary tract infections in children. BMC Infectious Diseases , 23 (1) , Article 400. 10.1186/s12879-023-08356-z. Green open access

[thumbnail of quality indicators for appropriate antibiotic prescribing in UTI in children BMC Infectious Disease 2023.pdf]
Preview
PDF
quality indicators for appropriate antibiotic prescribing in UTI in children BMC Infectious Disease 2023.pdf - Published Version

Download (1MB) | Preview

Abstract

BACKGROUND: The aim of this study was to define a set of urinary tract infections (UTIs)-specific quality indicators for appropriate prescribing in children and evaluate clinical practices in a district general hospital in Greece. METHODS: The aim of this study was to define a set of urinary tract infections (UTIs)-specific quality indicators for appropriate prescribing in children and evaluate clinical practices in a district general hospital in Greece. METHODS: The aim of this study was to define a set of urinary tract infections (UTIs)-specific quality indicators for appropriate prescribing in children and evaluate clinical practices in a district general hospital in Greece. RESULTS: Twelve quality indicators were adapted or developed for prescribing in childhood UTIs. A broad variety of antibiotics were prescribed for UTIs, with a drug utilization (DU) 90% rate of 6 and 9 different antibiotics for febrile and afebrile UTIs, respectively. Despite the low incidence of multi-drug resistant UTIs in the study period (9/261, 3.4%), broad-spectrum antibiotics were prescribed in 33.5% (164/490) of prescriptions. A total of 62.8% (164/261) of patients were started on empiric combined therapies, while opportunities to de-escalate were missed in 37.8% (62/164) of them. One quarter (67/261, 25.7%) of patients did not fulfil the criteria for receiving treatment, while nearly half of those prescribed prophylaxis (82/175, 46.9%) could have avoided having a prophylaxis prescription. CONCLUSIONS: Our study identified substantial gaps for improvement in antimicrobial prescribing for UTIs in children. The application of the proposed quality indicators could help to limit unnecessary antibiotics use in children with UTI.

Type: Article
Title: Quality indicators for appropriate antibiotic prescribing in urinary tract infections in children
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s12879-023-08356-z
Publisher version: https://doi.org/10.1186/s12879-023-08356-z
Language: English
Additional information: © 2023 BioMed Central Ltd. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Antibiotics, Urinary tract infections, Children, Appropriate prescribing, Quality indicators, Antimicrobial stewardship
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10171952
Downloads since deposit
9Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item