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Mouse frontal cortex mediates additive multisensory decisions

Coen, Philip; Sit, Timothy PH; Wells, Miles J; Carandini, Matteo; Harris, Kenneth D; (2023) Mouse frontal cortex mediates additive multisensory decisions. Neuron 10.1016/j.neuron.2023.05.008. (In press). Green open access

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Abstract

The brain can combine auditory and visual information to localize objects. However, the cortical substrates underlying audiovisual integration remain uncertain. Here, we show that mouse frontal cortex combines auditory and visual evidence; that this combination is additive, mirroring behavior; and that it evolves with learning. We trained mice in an audiovisual localization task. Inactivating frontal cortex impaired responses to either sensory modality, while inactivating visual or parietal cortex affected only visual stimuli. Recordings from >14,000 neurons indicated that after task learning, activity in the anterior part of frontal area MOs (secondary motor cortex) additively encodes visual and auditory signals, consistent with the mice's behavioral strategy. An accumulator model applied to these sensory representations reproduced the observed choices and reaction times. These results suggest that frontal cortex adapts through learning to combine evidence across sensory cortices, providing a signal that is transformed into a binary decision by a downstream accumulator.

Type: Article
Title: Mouse frontal cortex mediates additive multisensory decisions
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2023.05.008
Publisher version: https://doi.org/10.1016/j.neuron.2023.05.008
Language: English
Additional information: © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: audiovisual, decision-making, mixed selectivity, neural coding, optogenetics, parietal cortex, prefrontal cortex, visual cortex
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10171890
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