Krop, Juliette;
van der Meeren, Lotte E;
van der Hoorn, Marie-Louise P;
Ijsselsteijn, Marieke E;
Dijkstra, Kyra L;
Kapsenberg, H;
van der Keur, C;
... Bos, Manon; + view all
(2023)
Identification of a unique intervillous cellular signature in chronic histiocytic intervillositis.
Placenta
, 139
pp. 34-42.
10.1016/j.placenta.2023.05.007.
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Abstract
Introduction: Chronic histiocytic intervillositis (CHI) is a rare histopathological lesion in the placenta characterized by an infiltrate of CD68+ cells in the intervillous space. CHI is associated with adverse pregnancy outcomes such as miscarriage, fetal growth restriction, and (late) intrauterine fetal death. The adverse pregnancy outcomes and a variable recurrence rate of 25–100% underline its clinical relevance. The pathophysiologic mechanism of CHI is unclear, but it appears to be immunologically driven. The aim of this study was to obtain a better understanding of the phenotype of the cellular infiltrate in CHI. Method: We used imaging mass cytometry to achieve in-depth visualization of the intervillous maternal immune cells and investigated their spatial orientation in situ in relation to the fetal syncytiotrophoblast. Results: We found three phenotypically distinct CD68+HLA-DR+CD38+ cell clusters that were unique for CHI. Additionally, syncytiotrophoblast cells in the vicinity of these CD68+HLA-DR+CD38+ cells showed decreased expression of the immunosuppressive enzyme CD39. Discussion: The current results provide novel insight into the phenotype of CD68+ cells in CHI. The identification of unique CD68+ cell clusters will allow more detailed analysis of their function and could result in novel therapeutic targets for CHI.
| Type: | Article |
|---|---|
| Title: | Identification of a unique intervillous cellular signature in chronic histiocytic intervillositis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.placenta.2023.05.007 |
| Publisher version: | https://doi.org/10.1016/j.placenta.2023.05.007 |
| Language: | English |
| Additional information: | /© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10171876 |
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