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Somatosensory-Evoked Early Sharp Waves in the Neonatal Rat Hippocampus

Gainutdinov, A; Shipkov, D; Sintsov, M; Fabrizi, L; Nasretdinov, A; Khazipov, R; Valeeva, G; (2023) Somatosensory-Evoked Early Sharp Waves in the Neonatal Rat Hippocampus. International Journal of Molecular Sciences , 24 (10) , Article 8721. 10.3390/ijms24108721. Green open access

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Abstract

The developing entorhinal–hippocampal system is embedded within a large-scale bottom-up network, where spontaneous myoclonic movements, presumably via somatosensory feedback, trigger hippocampal early sharp waves (eSPWs). The hypothesis, that somatosensory feedback links myoclonic movements with eSPWs, implies that direct somatosensory stimulation should also be capable of evoking eSPWs. In this study, we examined hippocampal responses to electrical stimulation of the somatosensory periphery in urethane-anesthetized, immobilized neonatal rat pups using silicone probe recordings. We found that somatosensory stimulation in ~33% of the trials evoked local field potential (LFP) and multiple unit activity (MUA) responses identical to spontaneous eSPWs. The somatosensory-evoked eSPWs were delayed from the stimulus, on average, by 188 ms. Both spontaneous and somatosensory-evoked eSPWs (i) had similar amplitude of ~0.5 mV and half-duration of ~40 ms, (ii) had similar current-source density (CSD) profiles, with current sinks in CA1 strata radiatum, lacunosum-moleculare and DG molecular layer and (iii) were associated with MUA increase in CA1 and DG. Our results indicate that eSPWs can be triggered by direct somatosensory stimulations and support the hypothesis that sensory feedback from movements is involved in the association of eSPWs with myoclonic movements in neonatal rats.

Type: Article
Title: Somatosensory-Evoked Early Sharp Waves in the Neonatal Rat Hippocampus
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/ijms24108721
Publisher version: https://doi.org/10.3390/ijms24108721
Language: English
Additional information: © 2023 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: hippocampus; CA1; dentate gyrus; sharp wave; neonatal rat; somatosensory; sensory-evoked response; local field potentials; multiple unit activity; current-source density
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10171859
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