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Hedgehog signalling in allograft vasculopathy: a new therapeutic target?

Rowell, Jasmine; Lau, Ching-In; Yánez, Diana C; Zhang, Eden; Crompton, Tessa; (2023) Hedgehog signalling in allograft vasculopathy: a new therapeutic target? Trends in Pharmacological Sciences 10.1016/j.tips.2023.05.005. (In press). Green open access

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Abstract

Allograft vasculopathy (AV) leads to chronic rejection of organ transplants, but its causes are obscure. New research from the Jane-Wit laboratory showed that Sonic Hedgehog (SHH) signalling from damaged graft endothelium drives vasculopathy by promoting proinflammatory cytokine production and NLRP3-inflammasome activation in alloreactive CD4+PTCH1hiPD-1hiT memory cells, offering new diagnostic and therapeutic strategies.

Type: Article
Title: Hedgehog signalling in allograft vasculopathy: a new therapeutic target?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tips.2023.05.005
Publisher version: https://doi.org/10.1016/j.tips.2023.05.005
Language: English
Additional information: © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
Keywords: Sonic Hedgehog (SHH), CD4 T cell, SMO, NLRP3, inflammasome, ZFYVE21
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10171855
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