Rowell, Jasmine;
Lau, Ching-In;
Yánez, Diana C;
Zhang, Eden;
Crompton, Tessa;
(2023)
Hedgehog signalling in allograft vasculopathy: a new therapeutic target?
Trends in Pharmacological Sciences
10.1016/j.tips.2023.05.005.
(In press).
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Abstract
Allograft vasculopathy (AV) leads to chronic rejection of organ transplants, but its causes are obscure. New research from the Jane-Wit laboratory showed that Sonic Hedgehog (SHH) signalling from damaged graft endothelium drives vasculopathy by promoting proinflammatory cytokine production and NLRP3-inflammasome activation in alloreactive CD4+PTCH1hiPD-1hiT memory cells, offering new diagnostic and therapeutic strategies.
| Type: | Article |
|---|---|
| Title: | Hedgehog signalling in allograft vasculopathy: a new therapeutic target? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tips.2023.05.005 |
| Publisher version: | https://doi.org/10.1016/j.tips.2023.05.005 |
| Language: | English |
| Additional information: | © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/). |
| Keywords: | Sonic Hedgehog (SHH), CD4 T cell, SMO, NLRP3, inflammasome, ZFYVE21 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10171855 |
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