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Ceramic Materials for 3D Printing of Biomimetic Bone Scaffolds – Current state–of–the–art & Future Perspectives

Budharaju, Harshavardhan; Suresh, Shruthy; Parkkavi Sekar, Muthu; De Vega, Brigita; Sethuraman, Swaminathan; Sundaramurthi, Dhakshinamoorthy; Kalaskar, Deepak M; (2023) Ceramic Materials for 3D Printing of Biomimetic Bone Scaffolds – Current state–of–the–art & Future Perspectives. Materials & Design , Article 112064. 10.1016/j.matdes.2023.112064. Green open access

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Abstract

Ceramic bone implants have potential properties ideal for long-term implantation applications. On comparison with other materials, ceramic biomaterials have advantages such as biocompatibility, low cost, osteoconductivity, osteoinductivity, corrosion resistance, and can be made into various shapes with desired surface properties. Among transplantation surgeries, bone transplantation is the second largest in the globe after blood transfusion which is an indication for rising hope on the potential treatment options for bone. 3D printing is one of the most advanced fabrication techniques to create customized bone implants using materials such as ceramics and their composites. Developing bone scaffolds that precisely recapitulate the mechanical properties and other biological functions of bone remains a major challenge. However, extensive research on ceramic biomaterials have resulted in the successful 3D printing of complex bony designs with >50% porosity with cortical bone mechanical properties. This review critically analyses the use of various 3D printing techniques to fabricate ceramic bone scaffolds. Further, various natural and synthetic ceramic materials for producing customized ceramic implants are discussed along with potential clinical applications. Finally, a list of companies that offer customized 3D printed implants and the future on clinical translation of 3D printed ceramic bone implants are outlined.

Type: Article
Title: Ceramic Materials for 3D Printing of Biomimetic Bone Scaffolds – Current state–of–the–art & Future Perspectives
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.matdes.2023.112064
Publisher version: https://doi.org/10.1016/j.matdes.2023.112064
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Ceramics, Bone grafts, 3D printing, Bone tissue engineering, Synthetic bone scaffolds, Hydroxyapatite
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10171702
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