UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Growth factors and their peptide mimetics for treatment of traumatic brain injury

Dickman, Rachael; Atkinson, Emily; (2023) Growth factors and their peptide mimetics for treatment of traumatic brain injury. Bioorganic and Medicinal Chemistry , 90 , Article 117368. 10.1016/j.bmc.2023.117368. Green open access

[thumbnail of Dickman_1-s2.0-S096808962300216X-main.pdf]
Preview
Text
Dickman_1-s2.0-S096808962300216X-main.pdf

Download (9MB) | Preview

Abstract

Traumatic brain injury (TBI) is a leading cause of disability in adults, caused by a physical insult damaging the brain. Growth factor-based therapies have the potential to reduce the effects of secondary injury and improve outcomes by providing neuroprotection against glutamate excitotoxicity, oxidative damage, hypoxia, and ischemia, as well as promoting neurite outgrowth and the formation of new blood vessels. Despite promising evidence in preclinical studies, few neurotrophic factors have been tested in clinical trials for TBI. Translation to the clinic is not trivial and is limited by the short in vivo half-life of the protein, the inability to cross the blood–brain barrier and human delivery systems. Synthetic peptide mimetics have the potential to be used in place of recombinant growth factors, activating the same downstream signalling pathways, with a decrease in size and more favourable pharmacokinetic properties. In this review, we will discuss growth factors with the potential to modulate damage caused by secondary injury mechanisms following a traumatic brain injury that have been trialled in other indications including spinal cord injury, stroke and neurodegenerative diseases. Peptide mimetics of nerve growth factor (NGF), hepatocyte growth factor (HGF), glial cell line-derived growth factor (GDNF), brain-derived neurotrophic factor (BDNF), platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) will be highlighted, most of which have not yet been tested in preclinical or clinical models of TBI.

Type: Article
Title: Growth factors and their peptide mimetics for treatment of traumatic brain injury
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bmc.2023.117368
Publisher version: https://doi.org/10.1016/j.bmc.2023.117368
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Growth factors, Peptide mimetics, Secondary injury, Traumatic brain injury
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10171701
Downloads since deposit
45Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item