Johnston, Jenessa N;
Greenwald, Maximillian S;
Henter, Ioline D;
Kraus, Christoph;
Mkrtchian, Anahit;
Clark, Neil G;
Park, Lawrence T;
... Kadriu, Bashkim; + view all
(2023)
Inflammation, stress and depression: An exploration of ketamine's therapeutic profile.
Drug Discovery Today
, 28
(4)
, Article 103518. 10.1016/j.drudis.2023.103518.
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Abstract
Well-established animal models of depression have described a proximal relationship between stress and central nervous system (CNS) inflammation - a relationship mirrored in the peripheral inflammatory biomarkers of individuals with depression. Evidence also suggests that stress-induced proinflammatory states can contribute to the neurobiology of treatment-resistant depression. Interestingly, ketamine, a rapid-acting antidepressant, can partially exert its therapeutic effects via anti-inflammatory actions on the hypothalamic-pituitary adrenal (HPA) axis, the kynurenine pathway or by cytokine suppression. Further investigations into the relationship between ketamine, inflammation and stress could provide insight into ketamine's unique therapeutic mechanisms and stimulate efforts to develop rapid-acting, anti-inflammatory-based antidepressants.
| Type: | Article |
|---|---|
| Title: | Inflammation, stress and depression: An exploration of ketamine's therapeutic profile |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.drudis.2023.103518 |
| Publisher version: | https://doi.org/10.1016/j.drudis.2023.103518 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Ketamine, depression, stress, inflammation, treatment-resistant depression, anhedonia |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Mental Health Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10171700 |
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