de Brouwer, Remco;
Te Rijdt, Wouter P;
Hoorntje, Edgar T;
Amin, Ahmad;
Asselbergs, Folkert W;
Cox, Moniek GPJ;
van der Heijden, Jeroen F;
... van den Berg, Maarten P; + view all
(2023)
A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
European Heart Journal
10.1093/eurheartj/ehad292.
(In press).
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Abstract
INTRODUCTION Phospholamban (PLN; p.Arg14del) cardiomyopathy is an inherited disease caused by the pathogenic p.Arg14del variant in the PLN gene. Clinically, it is characterized by malignant ventricular arrhythmias and progressive heart failure.1,2 Cardiac fibrotic tissue remodelling occurs early on in PLN p.Arg14del carriers.3,4 Eplerenone was deemed a treatment candidate because of its beneficial effects on ventricular remodelling and antifibrotic properties.5,6 We conducted the multicentre randomized trial ‘intervention in PHOspholamban RElated CArdiomyopathy STudy’ (i-PHORECAST) to assess whether treatment with eplerenone of asymptomatic PLN p.Arg14del carriers attenuates disease onset and progression.
| Type: | Article |
|---|---|
| Title: | A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/eurheartj/ehad292 |
| Publisher version: | https://doi.org/10.1093/eurheartj/ehad292 |
| Language: | English |
| Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| Keywords: | Cardiomyopathy, Eplerenone, Fibrosis, Heart failure, Phospholamban, Randomized clinical trial |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics > Clinical Epidemiology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10171580 |
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