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A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers

de Brouwer, Remco; Te Rijdt, Wouter P; Hoorntje, Edgar T; Amin, Ahmad; Asselbergs, Folkert W; Cox, Moniek GPJ; van der Heijden, Jeroen F; ... van den Berg, Maarten P; + view all (2023) A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers. European Heart Journal 10.1093/eurheartj/ehad292. (In press). Green open access

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Abstract

INTRODUCTION Phospholamban (PLN; p.Arg14del) cardiomyopathy is an inherited disease caused by the pathogenic p.Arg14del variant in the PLN gene. Clinically, it is characterized by malignant ventricular arrhythmias and progressive heart failure.1,2 Cardiac fibrotic tissue remodelling occurs early on in PLN p.Arg14del carriers.3,4 Eplerenone was deemed a treatment candidate because of its beneficial effects on ventricular remodelling and antifibrotic properties.5,6 We conducted the multicentre randomized trial ‘intervention in PHOspholamban RElated CArdiomyopathy STudy’ (i-PHORECAST) to assess whether treatment with eplerenone of asymptomatic PLN p.Arg14del carriers attenuates disease onset and progression.

Type: Article
Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/eurheartj/ehad292
Publisher version: https://doi.org/10.1093/eurheartj/ehad292
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Keywords: Cardiomyopathy, Eplerenone, Fibrosis, Heart failure, Phospholamban, Randomized clinical trial
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: https://discovery.ucl.ac.uk/id/eprint/10171580
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