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Dying To Find Out: The Cost of Time at the Dawn of the Multicancer Early Detection Era

Klein, Eric A; Madhavan, Sarina; Beer, Tomasz M; Bettegowda, Chetan; Liu, Minetta C; Hartman, Anne-Renee; Hackshaw, Allan; (2023) Dying To Find Out: The Cost of Time at the Dawn of the Multicancer Early Detection Era. Cancer Epidemiology, Biomarkers & Prevention 10.1158/1055-9965.EPI-22-1275. (In press). Green open access

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Abstract

Cancer is a significant burden worldwide that adversely impacts life expectancy, quality of life, health care costs, and workforce productivity. Although currently recommended screening tests for individual cancers reduce mortality, they detect only a minority of all cancers and sacrifice specificity for high sensitivity, resulting in a high cumulative rate of false positives. Blood-based multicancer early detection tests (MCED) based on next-generation sequencing (NGS) and other technologies hold promise for broadening the number of cancer types detected in screened populations and hope for reducing cancer mortality. The promise of this new technology to improve cancer detection rates and make screening more efficient at the population level demands the development of novel trial designs that accelerate clinical adoption. Carefully designed clinical trials are needed to address these issues.

Type: Article
Title: Dying To Find Out: The Cost of Time at the Dawn of the Multicancer Early Detection Era
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1158/1055-9965.EPI-22-1275
Publisher version: https://doi.org/10.1158/1055-9965.EPI-22-1275
Language: English
Additional information: © 2023 The Authors; Published by the American Association for Cancer Research. This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license (http://creativecommons.org/licenses/by-nc-nd/4.0).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre
URI: https://discovery.ucl.ac.uk/id/eprint/10171341
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