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Cortico-cortical feedback engages active dendrites in visual cortex

Fişek, Mehmet; Herrmann, Dustin; Egea-Weiss, Alexander; Cloves, Matilda; Bauer, Lisa; Lee, Tai-Ying; Russell, Lloyd E; (2023) Cortico-cortical feedback engages active dendrites in visual cortex. Nature , 617 (7962) pp. 769-776. 10.1038/s41586-023-06007-6. Green open access

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Abstract

Sensory processing in the neocortex requires both feedforward and feedback information flow between cortical areas 1. In feedback processing, higher-level representations provide contextual information to lower levels, and facilitate perceptual functions such as contour integration and figure–ground segmentation 2,3. However, we have limited understanding of the circuit and cellular mechanisms that mediate feedback influence. Here we use long-range all-optical connectivity mapping in mice to show that feedback influence from the lateromedial higher visual area (LM) to the primary visual cortex (V1) is spatially organized. When the source and target of feedback represent the same area of visual space, feedback is relatively suppressive. By contrast, when the source is offset from the target in visual space, feedback is relatively facilitating. Two-photon calcium imaging data show that this facilitating feedback is nonlinearly integrated in the apical tuft dendrites of V1 pyramidal neurons: retinotopically offset (surround) visual stimuli drive local dendritic calcium signals indicative of regenerative events, and two-photon optogenetic activation of LM neurons projecting to identified feedback-recipient spines in V1 can drive similar branch-specific local calcium signals. Our results show how neocortical feedback connectivity and nonlinear dendritic integration can together form a substrate to support both predictive and cooperative contextual interactions.

Type: Article
Title: Cortico-cortical feedback engages active dendrites in visual cortex
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41586-023-06007-6
Publisher version: https://doi.org/10.1038/s41586-023-06007-6
Language: English
Additional information: This paper was originally published under a standard Springer Nature license (© The Author(s), under exclusive licence to Springer Nature Limited). It is now available as an open-access paper under a Creative Commons Attribution 4.0 International license, © The Author(s). The error has been corrected in the HTML and PDF versions of the article.
Keywords: Mice, Animals, Feedback, Calcium, Neurons, Dendrites, Visual Cortex, Visual Pathways
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10171274
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