Yellon, Derek M;
Beikoghli Kalkhoran, Siavash;
Davidson, Sean M;
(2023)
The RISK pathway leading to mitochondria and cardioprotection: how everything started.
Basic Research in Cardiology
, 118
(1)
, Article 22. 10.1007/s00395-023-00992-5.
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Abstract
Ischaemic heart disease, which often manifests clinically as myocardial infarction (MI), remains a major cause of mortality worldwide. Despite the development of effective pre-clinical cardioprotective therapies, clinical translation has been disappointing. Nevertheless, the 'reperfusion injury salvage kinase' (RISK) pathway appears to be a promising target for cardioprotection. This pathway is crucial for the induction of cardioprotection by numerous pharmacological and non-pharmacological interventions, such as ischaemic conditioning. An important component of the cardioprotective effects of the RISK pathway involves the prevention of mitochondrial permeability transition pore (MPTP) opening and subsequent cardiac cell death. Here, we will review the historical perspective of the RISK pathway and focus on its interaction with mitochondria in the setting of cardioprotection.
| Type: | Article |
|---|---|
| Title: | The RISK pathway leading to mitochondria and cardioprotection: how everything started |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00395-023-00992-5 |
| Publisher version: | https://doi.org/10.1007/s00395-023-00992-5 |
| Language: | English |
| Additional information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Humans, Ischemic Preconditioning, Myocardial, Mitochondria, Mitochondria, Heart, Mitochondrial Membrane Transport Proteins, Mitochondrial Permeability Transition Pore, Myocardial Ischemia, Myocardial Reperfusion Injury, Ischaemia–reperfusion injury, Ischaemic preconditioning, Mitochondria, MPTP, PI3Kα, RISK pathway |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10171076 |
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