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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Zeleznik, OA; Kang, JH; Lasky-Su, J; Eliassen, AH; Frueh, L; Clish, CB; Rosner, BA; ... Pasquale, LR; + view all (2023) Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank. Nature Communications , 14 (1) , Article 2860. 10.1038/s41467-023-38466-w. Green open access

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Abstract

Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma is the most common form, and yet the etiology of this multifactorial disease is poorly understood. We aimed to identify plasma metabolites associated with the risk of developing POAG in a case-control study (599 cases and 599 matched controls) nested within the Nurses' Health Studies, and Health Professionals' Follow-Up Study. Plasma metabolites were measured with LC-MS/MS at the Broad Institute (Cambridge, MA, USA); 369 metabolites from 18 metabolite classes passed quality control analyses. For comparison, in a cross-sectional study in the UK Biobank, 168 metabolites were measured in plasma samples from 2,238 prevalent glaucoma cases and 44,723 controls using NMR spectroscopy (Nightingale, Finland; version 2020). Here we show higher levels of diglycerides and triglycerides are adversely associated with glaucoma in all four cohorts, suggesting that they play an important role in glaucoma pathogenesis.

Type: Article
Title: Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41467-023-38466-w
Publisher version: https://doi.org/10.1038/s41467-023-38466-w
Language: English
Additional information: © 2023 Springer Nature Limited. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10171061
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