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Biodegradable and Sustainable Synthetic Antibodies—A Perspective

Ma, Xiaohan; Knowles, Jonathan C; Poma, Alessandro; (2023) Biodegradable and Sustainable Synthetic Antibodies—A Perspective. Pharmaceutics , 15 (5) , Article 1440. 10.3390/pharmaceutics15051440. Green open access

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Abstract

Molecular imprinting technology has been around for almost a century, and we have witnessed dramatic advancements in the overall design and production of molecularly imprinted polymers (MIPs), particularly in terms of possible formats of the final products when it comes to truly resembling antibody substitutes, i.e., MIP nanoparticles (MIP NPs). Nonetheless, the overall technology appears to struggle to keep up with the current global sustainability efforts, as recently elucidated in the latest comprehensive reviews, which introduced the “GREENIFICATION” concept. In this review, we will try to elucidate if these advancements in MIP nanotechnology have indeed resulted in a sustainability amelioration. We will do so by discussing the general production and purification strategies for MIP NPs, specifically from a sustainability and biodegradation perspective, also considering the final intended application and ultimate waste management.

Type: Article
Title: Biodegradable and Sustainable Synthetic Antibodies—A Perspective
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/pharmaceutics15051440
Publisher version: https://doi.org/10.3390/pharmaceutics15051440
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Molecular imprinting; molecularly imprinted polymers; nanoparticles; synthetic antibodies; biodegradable polymers; sustainable imprinting; sustainability
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10169947
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