Ashmore, Jonathan F;
Oghalai, John S;
Dewey, James B;
Olson, Elizabeth S;
Strimbu, Clark E;
Wang, Yi;
Shera, Christopher A;
... Raphael, Robert M; + view all
(2023)
The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.
Journal of the Association for Research in Otolaryngology
, 24
(2)
pp. 117-127.
10.1007/s10162-022-00852-4.
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Abstract
In 1985, Bill Brownell and colleagues published the remarkable observation that cochlear outer hair cells (OHCs) express voltage-driven mechanical motion: electromotility. They proposed OHC electromotility as the mechanism for the elusive “cochlear amplifier” required to explain the sensitivity of mammalian hearing. The finding and hypothesis stimulated an explosion of experiments that have transformed our understanding of cochlear mechanics and physiology, the evolution of hair cell structure and function, and audiology. Here, we bring together examples of current research that illustrate the continuing impact of the discovery of OHC electromotility.
| Type: | Article |
|---|---|
| Title: | The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10162-022-00852-4 |
| Publisher version: | https://doi.org/10.1007/s10162-022-00852-4 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Prestin, Cochlear Amplifier, Optical Coherence Tomography, Otoacoustic Emissions, Efferent |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10169937 |
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