UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Hippocampal theta activity during encoding promotes subsequent associative memory in humans

Joensen, Bárður H; Bush, Daniel; Vivekananda, Umesh; Horner, Aidan J; Bisby, James A; Diehl, Beate; Miserocchi, Anna; ... Burgess, Neil; + view all (2023) Hippocampal theta activity during encoding promotes subsequent associative memory in humans. Cerebral Cortex , Article bhad162. 10.1093/cercor/bhad162. Green open access

[thumbnail of bhad162.pdf]
Preview
Text
bhad162.pdf - Published Version

Download (810kB) | Preview

Abstract

Hippocampal theta oscillations have been implicated in associative memory in humans. However, findings from electrophysiological studies using scalp electroencephalography or magnetoencephalography, and those using intracranial electroencephalography are mixed. Here we asked 10 pre-surgical epilepsy patients undergoing intracranial electroencephalography recording, along with 21 participants undergoing magnetoencephalography recordings, to perform an associative memory task, and examined whether hippocampal theta activity during encoding was predictive of subsequent associative memory performance. Across the intracranial electroencephalography and magnetoencephalography studies, we observed that theta power in the hippocampus increased during encoding, and that this increase differed as a function of subsequent memory, with greater theta activity for pairs that were successfully retrieved in their entirety compared with those that were not remembered. This helps to clarify the role of theta oscillations in associative memory formation in humans, and further, demonstrates that findings in epilepsy patients undergoing intracranial electroencephalography recordings can be extended to healthy participants undergoing magnetoencephalography recordings.

Type: Article
Title: Hippocampal theta activity during encoding promotes subsequent associative memory in humans
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cercor/bhad162
Publisher version: http://doi.org/10.1093/cercor/bhad162
Language: English
Additional information: © The Author(s) 2023. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: MEG, associative memory, hippocampus, intracranial EEG, theta oscillations
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10169798
Downloads since deposit
141Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item