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Senescent T cells: Beneficial and detrimental roles

Laphanuwat, P; Gomes, DCO; Akbar, AN; (2023) Senescent T cells: Beneficial and detrimental roles. Immunological Reviews 10.1111/imr.13206. (In press). Green open access

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Abstract

As the thymus involutes during aging, the T-cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward replicative senescence, due to telomere erosion. This review discusses mechanisms that regulate the end-stage differentiation (senescence) of T cells. Although these cells, within both CD4 and CD8 compartments, lose proliferative activity after antigen-specific challenge, they acquire innate-like immune function. While this may confer broad immune protection during aging, these senescent T cells may also cause immunopathology, especially in the context of excessive inflammation in tissue microenvironments.

Type: Article
Title: Senescent T cells: Beneficial and detrimental roles
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/imr.13206
Publisher version: https://doi.org/10.1111/imr.13206
Language: English
Additional information: Copyright © 2023 The Authors. Immunological Reviews published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: aging, senescence, T cell, TEMRA, terminally differentiated cell
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10169709
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