Mason, William J;
Vasilopoulou, Elisavet;
(2023)
The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus.
International Journal of Molecular Sciences
, 24
(9)
, Article 7684. 10.3390/ijms24097684.
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Abstract
Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease progression. New strategies are needed to slow the progression to end-stage kidney disease, which requires dialysis or transplantation. Thymosin β4 (Tβ4), an endogenous peptide that sequesters G-actin, has shown potent anti-inflammatory function in experimental models of heart, kidney, liver, lung, and eye injury. In this review, we discuss the role of endogenous and exogenous Tβ4 in glomerular disease progression and the current understanding of the underlying mechanisms.
| Type: | Article |
|---|---|
| Title: | The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/ijms24097684 |
| Publisher version: | https://doi.org/10.3390/ijms24097684 |
| Language: | English |
| Additional information: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Thymosin β4; glomerulus; podocyte; macrophage; chronic kidney disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10169675 |
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