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Non-linear effects and effect modification at the participant-level in IPD meta-analysis part 2: Methodological guidance is available

Marlin, Nadine; Godolphin, Peter J; Hooper, Richard; Riley, Richard; Rogozinska, Ewelina; (2023) Non-linear effects and effect modification at the participant-level in IPD meta-analysis part 2: Methodological guidance is available. Journal of Clinical Epidemiology , 159 pp. 319-329. 10.1016/j.jclinepi.2023.04.014. Green open access

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Abstract

OBJECTIVE: To review methodological guidance for non-linear associations (NL), and linear and non-linear effect modification (LEM and NLEM) at the participant level in individual participant data meta-analyses (IPDMAs) and their power requirements. STUDY DESIGN AND SETTING: We searched Medline, Embase, Web of Science, Scopus, PsycINFO and the Cochrane Library to identify methodology publications on IPDMA of LEM, NL or NLEM (PROSPERO CRD42019126768). RESULTS: Through screening 6466 records we identified 54 potential articles of which 23 full texts were relevant. Nine further relevant publications were published before or after the literature search and were added. Of these 32 references, 21 articles considered LEM, 6 articles NL or NLEM and 6 articles described sample size calculations. A book described all four. Sample size may be calculated through simulation or closed form. Assessments of LEM or NLEM at the participant level need to be based on within-trial information alone. Non-linearity (NL or NLEM) can be modelled using polynomials or splines to avoid categorisation. CONCLUSION: Detailed methodological guidance on IPDMA of effect modification at participant-level is available. However, methodology papers for sample size and non-linearity are rarer and may not cover all scenarios. On these aspects, further guidance is needed.

Type: Article
Title: Non-linear effects and effect modification at the participant-level in IPD meta-analysis part 2: Methodological guidance is available
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jclinepi.2023.04.014
Publisher version: https://doi.org/10.1016/j.jclinepi.2023.04.014
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Effect modification, Individual participant data meta-analysis, Methodology, Non-linear, Sample size, interaction
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10169605
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