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Sculpting with stiffness: rigidity as a regulator of morphogenesis

Shellard, Adam; Mayor, Roberto; (2023) Sculpting with stiffness: rigidity as a regulator of morphogenesis. Biochemical Society Transactions 10.1042/BST20220826. (In press). Green open access

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Abstract

From a physical perspective, morphogenesis of tissues results from interplay between their material properties and the mechanical forces exerted on them. The importance of mechanical forces in influencing cell behaviour is widely recognised, whereas the importance of tissue material properties in vivo, like stiffness, has only begun to receive attention in recent years. In this mini-review, we highlight key themes and concepts that have emerged related to how tissue stiffness, a fundamental material property, guides various morphogenetic processes in living organisms.

Type: Article
Title: Sculpting with stiffness: rigidity as a regulator of morphogenesis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/BST20220826
Publisher version: https://doi.org/10.1042/BST20220826
Language: English
Additional information: © 2023 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
Keywords: development, mechanics, morphogenesis, rigidity, robustness, stiffness
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10169511
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