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Perspectives on the Risk-Stratified Treatment of Multiple Myeloma

Davies, Faith E; Pawlyn, Charlotte; Usmani, Saad Z; San-Miguel, Jesus F; Einsele, Hermann; Boyle, Eileen M; Corre, Jill; ... Morgan, Gareth J; + view all (2022) Perspectives on the Risk-Stratified Treatment of Multiple Myeloma. Blood Cancer Discovery , 3 (4) pp. 273-284. 10.1158/2643-3230.BCD-21-0205. Green open access

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Abstract

The multiple myeloma treatment landscape has changed dramatically. This change, paralleled by an increase in scientific knowledge, has resulted in significant improvement in survival. However, heterogeneity remains in clinical outcomes, with a proportion of patients not benefiting from current approaches and continuing to have a poor prognosis. A significant proportion of the variability in outcome can be predicted on the basis of clinical and biochemical parameters and tumor-acquired genetic variants, allowing for risk stratification and a more personalized approach to therapy. This article discusses the principles that can enable the rational and effective development of therapeutic approaches for high-risk multiple myeloma.

Type: Article
Title: Perspectives on the Risk-Stratified Treatment of Multiple Myeloma
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1158/2643-3230.BCD-21-0205
Publisher version: https://doi.org/10.1158/2643-3230.BCD-21-0205
Language: English
Additional information: ©2022 The Authors; Published by the American Association for Cancer Research This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. http://creativecommons.org/licenses/by-nc-nd/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10169408
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