Caxaria, S;
Bharde, S;
Fuller, AM;
Evans, R;
Thomas, B;
Celik, P;
Dell'Accio, F;
... Sikandar, S; + view all
(2023)
Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia.
Proceedings of the National Academy of Sciences of the United States of America
, 120
(17)
, Article e2211631120. 10.1073/pnas.2211631120.
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Abstract
Fibromyalgia is a debilitating widespread chronic pain syndrome that occurs in 2 to 4% of the population. The prevailing view that fibromyalgia results from central nervous system dysfunction has recently been challenged with data showing changes in peripheral nervous system activity. Using a mouse model of chronic widespread pain through hyperalgesic priming of muscle, we show that neutrophils invade sensory ganglia and confer mechanical hypersensitivity on recipient mice, while adoptive transfer of immunoglobulin, serum, lymphocytes, or monocytes has no effect on pain behavior. Neutrophil depletion abolishes the establishment of chronic widespread pain in mice. Neutrophils from patients with fibromyalgia also confer pain on mice. A link between neutrophil-derived mediators and peripheral nerve sensitization is already established. Our observations suggest approaches for targeting fibromyalgia pain via mechanisms that cause altered neutrophil activity and interactions with sensory neurons.
| Type: | Article |
|---|---|
| Title: | Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1073/pnas.2211631120 |
| Publisher version: | https://doi.org/10.1073/pnas.2211631120 |
| Language: | English |
| Additional information: | Copyright © 2023 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). |
| Keywords: | dorsal root ganglia, fibromyalgia, neuroimmune, neutrophils, pain, Humans, Chronic Pain, Fibromyalgia, Neutrophils, Hyperalgesia, Ganglia, Sensory |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10169224 |
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