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CD90 is not constitutively expressed in functional innate lymphoid cells

Schroeder, Jan-Hendrik; Beattie, Gordon; Lo, Jonathan W; Zabinski, Tomasz; Powell, Nick; Neves, Joana F; Jenner, Richard G; (2023) CD90 is not constitutively expressed in functional innate lymphoid cells. Frontiers in Immunology , 14 , Article 1113735. 10.3389/fimmu.2023.1113735. Green open access

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Abstract

Huge progress has been made in understanding the biology of innate lymphoid cells (ILC) by adopting several well-known concepts in T cell biology. As such, flow cytometry gating strategies and markers, such as CD90, have been applied to indentify ILC. Here, we report that most non-NK intestinal ILC have a high expression of CD90 as expected, but surprisingly a sub-population of cells exhibit low or even no expression of this marker. CD90-negative and CD90-low CD127+ ILC were present amongst all ILC subsets in the gut. The frequency of CD90-negative and CD90-low CD127+ ILC was dependent on stimulatory cues in vitro and enhanced by dysbiosis in vivo. CD90-negative and CD90-low CD127+ ILC were a potential source of IL-13, IFNγ and IL-17A at steady state and upon dysbiosis- and dextran sulphate sodium-elicited colitis. Hence, this study reveals that, contrary to expectations, CD90 is not constitutively expressed by functional ILC in the gut.

Type: Article
Title: CD90 is not constitutively expressed in functional innate lymphoid cells
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fimmu.2023.1113735
Publisher version: http://doi.org/10.3389/fimmu.2023.1113735
Language: English
Additional information: © 2023 Schroeder, Beattie, Lo, Zabinski, Powell, Neves, Jenner and Lord. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: innate lymphoid cell (ILC), CD90, intestine, DSS-colitis, fecal microbial transplant (FMT)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10169162
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